Analysis of on-the-job drug tests shows ‘significant decline’ in fentanyl use

Fentanyl use among U.S. workers dropped nearly 50% in 2025 based on on-the-job drug testing data from Quest Diagnostics. The significant decline suggests potential improvements in workplace safety and employee wellness across industries including construction.

Secaucus, NJ — The percentage of U.S. workers who tested positive for the synthetic opioid fentanyl decreased by nearly half in 2025, according to Quest Diagnostics’ annual Drug Testing Index. Researchers from the lab services provider analyzed results of random, on-the-job drug tests from both the…

This story was originally published by Safety+Health Magazine.